黑料社区

• Biography/ Background

  I have a long-standing interest in understanding the molecular mechanisms of bacterial pathogenesis, with emphasis on the characterisation of the virulence factors involved and evaluating the potential of candidate vaccine antigens.  My PhD was conducted under the joint supervision of Professor Paul Manning, Professor Ieva Kotlarski, and Associate Professor Renato Morona and entailed the functional characterisation of the SefA protein of Salmonella enterica serovar Enteritidis.

  I carried out my postdoctoral work in Professor James Paton’s laboratory from March 1997 to December 2009 on the molecular analysis of pneumococcal pathogenesis, and became a Senior Research Fellow from January 2010 to December 2014. 

  Throughout my research career, I have contributed significantly to the design and execution of research projects, international research grant applications and development of new technologies.  I have successfully co-supervised 4 Honours and 4 PhD students, and I currently co-supervise 2 PhD students.  In addition to my specific area of research, I have significantly harnessed my expertise and experience to mentor many graduate students, colleagues and postdoctoral fellows achieve the required success in their research.

  Over the years, I have developed numerous local, national and international networks of collaborations, which helped broaden the scope of my expertise, experience, achievements, and knowledge base.

   

• Qualifications

  PhD, The University of 黑料社区, 黑料社区, Australia.

  MSc, Obafemi Awolowo University, Ile-Ife, Nigeria.

  BSc [Hons] (First Class), University of Jos, Jos, Nigeria.

• Awards & Achievements

  Research Career Development Network (RCDN) Award (2012). School of Molecular and Biomedical Science, The University of 黑料社区.

   

  I have published over 60 manuscripts in bacterial pathogenesis (h index=26 as at 05/01/15).  I am first/joint first or corresponding author on 40% of these publications.  I publish regularly in First Rate Specialist Journals (Mol Microbiol, Infect Immun, and Microbiology-SGM). I also publish in First rate Non-specialist Journals, such as J Clin Invest, Cell Host & Microbe, Nature Comm, PLoS Pathogens, Structure and FASEB J. 

  I am an expert in bacterial pathogenesis, in vivo gene expression and vaccine development.

  I receive speaking invitations to national and international conferences on average once a year, and regularly involved in national (e.g. NHMRC) and international grant and manuscript reviews. I am also a co-inventor in one International Patent -PCT/KR2003/002929).

   

• Research Interests

  My research interest is primarily focused on understanding the molecular mechanisms of bacterial pathogenesis and host-pathogen interaction. In furtherance of these objectives, I employ contemporary molecular biology techniques and state-of-the-art technologies, including real-time quantitative reverse transcription PCR, microarray, in vivo gene expression, bioluminescent imaging, molecular cloning, targeted mutagenesis and protein expression and purification protocols. Furthermore, I use mouse challenge models and immunisation/challenge studies to gain a better understanding of bacterial pathogenesis and to characterise potential protein vaccine candidates.

• Research Funding

  CIA: Meningitis Research Foundation, UK Research grant (2008-2011).

  CIB: Channel 7 Research Foundation grant (2008).

  CIA: Channel 7 Research Foundation grant (2012-2013).

  CIB: National Health and Medical Research Council of Australia (NHMRC) Project Grant (2010-2014).

  CIB: Australian Research Council (ARC) Linkage Project with Gamma Vaccines (2012-2015).

   

   

• Publications

  Publications since 2000

  (*denotes joint first/corresponding author)

  Iwajomo OH, Moons P, Nkhata R, Mzinza D, Ogunniyi AD, Williams NA, Heyderman RS, Finn A. 2014. Delayed reconstitution of B cell immunity to pneumococcus in HIV-infected Malawian children on antiretroviral therapy. J Infect [IF = 4.0] DOI: http://dx.doi.org/10.1016/j.jinf.2014.10.011.

  Manso AS, Chai MH, Atack JM, Furi L, De Ste Croix M, Haigh R, Trappetti C, Ogunniyi AD, Shewell LK, Boitano M, Clark TA, Korlach J, Blades M, Mirkes E, Gorban AN, Paton JC, Jennings MP, Oggioni MR. (2014). A random six-phase switch regulates pneumococcal virulence via global epigenetic changes. Nat Commun. 2014 Sep 30;5:5055. doi: 10.1038/ncomms6055.

   Mahdi LK, Deihimi T, Zamansani F, Fruzangohar M, Adelson DL, Paton JC, *Ogunniyi AD, Ebrahimie E. (2014). A functional genomics catalogue of activated transcription factors during pathogenesis of pneumococcal disease. BMC Genomics. 15:769. doi: 10.1186/1471-2164-15-769.

  Plumptre CD, Eijkelkamp BA, Morey JR, Behr F, Couñago RM, Ogunniyi AD, Kobe B, O'Mara ML, Paton JC, McDevitt CA. (2014). AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae. Mol Microbiol 91:834-851.

  Plumptre CD, Ogunniyi AD, Paton JC. (2013). Surface Association of Pht Proteins of Streptococcus pneumoniae. Infect Immun. 81:3644-3651.

  Plumptre CD, Ogunniyi AD, Paton JC. (2013). Vaccination against Streptococcus pneumoniae Using Truncated Derivatives of Polyhistidine Triad Protein D. PLoS One. 8:e78916.

  Ogunniyi AD, Paton JC. (2013). Regulation of pneumococcal surface proteins and capsule. In Vasil ML, Darwin A (eds), Regulation of Bacterial Virulence. Washington DC: ASM Press, pp. 190-208.

  Mahdi LK, Ebrahimie E, Adelson DL, Paton JC, Ogunniyi AD. (2013). A Transcription Factor Contributes to Pathogenesis and Virulence in Streptococcus pneumoniae. PLoS One. 8:e70862.

  Iwajomo OH, Finn A, Ogunniyi AD, Williams NA, Heyderman RS. (2013). Impairment of Pneumococcal Antigen Specific Isotype-Switched Igg Memory B-Cell Immunity in HIV Infected Malawian Adults. PLoS One. 8.

  Fruzangohar M, Ebrahimie E, Ogunniyi AD, Mahdi LK, Paton JC, Adelson DL. (2013). Comparative GO: A Web Application for Comparative Gene Ontology and Gene Ontology-Based Gene Selection in Bacteria. PLoS One. 8:e78592.

  Basavanna S, Chimalapati S, Maqbool A, Rubbo B, Yuste J, Wilson RJ, Hosie A, Ogunniyi AD, Paton JC, Thomas G, Brown JS. (2013). The Effects of Methionine Acquisition and Synthesis on Streptococcus pneumoniae Growth and Virulence. PLoS One. 8:e49638.

   Brumshagen C, Maus R, Bischof A, Ueberberg B, Bohling J, Osterholzer JJ, Ogunniyi AD, Paton JC, Welte T, Maus UA. (2012). FMS-Like Tyrosine Kinase 3 Ligand Treatment of Mice Aggravates Acute Lung Injury in Response to Streptococcus pneumoniae: Role of Pneumolysin. Infect Immun. 80(12):4281-90.

  Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, Ogunniyi AD, Paton JC, Maus UA, Bauer M. (2012). Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB J. 26:2424-2436.

  Plumptre CD, Ogunniyi AD, Paton JC. 2012. Poly-histidine triad proteins of pathogenic streptococci. Trends in Microbiology. 20:485-493.

  Ogunniyi AD, Paton JC. (2012). Regulation of pneumococcal surface proteins and capsule. pp. 190-208. In: Vasil, M.L., and Darwin, A.J. (eds.). Regulation of Bacterial Virulence. ASM Press, Washington, DC.

  *Ogunniyi AD, Mahdi LK, Trappetti C, Verhoeven N, Mermans D, Van der Hoek MB, Plumptre CD, Paton JC. (2012). Identification of Genes That Contribute to Pathogenesis of Invasive Pneumococcal Disease by in vivo Transcriptomic Analysis. Infect Immun. 80(9):3268-3278.

  McAllister LJ, Ogunniyi AD, Stroeher UH, Paton JC. (2012). Contribution of a genomic accessory region encoding a putative cellobiose phosphotransferase system to virulence of Streptococcus pneumoniae. PLoS One. 7:e32385.

  Mahdi LK, Wang H, Van der Hoek MB, Paton JC, *Ogunniyi AD. (2012). Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice. J Clin Invest. 122:2208-2220.

  Trappetti C, *Ogunniyi AD, Oggioni MR, Paton JC. (2011). Extracellular matrix formation enhances the ability of Streptococcus pneumoniae to cause invasive disease. PLoS One. 6:e19844.

  Paton JC, Ogunniyi AD. (2011). Evicting the pneumococcus from its nasopharyngeal lodgings. Cell Host Microbe. 9:89-91.

  Ota MO, Oluwalana C, Howie SR, Gomez M, Ogunniyi AD, Mendy-Gomez AL, Owolabi O, Mureithi MW, Townend J, Secka O, Antonio M, Sutherland JS, Adegbola RA. (2011). Antibody and T-cell responses during acute and convalescent stages of invasive pneumococcal disease. Int J Infect Dis. 15:e282-288.

  McDevitt CA, Ogunniyi AD, Valkov E, Lawrence MC, Kobe B, McEwan AG, Paton JC. (2011). A molecular mechanism for bacterial susceptibility to zinc. PLoS Pathog. 7:e1002357.

  McAllister LJ, Ogunniyi AD, Stroeher UH, Leach AJ, Paton JC. (2011). Contribution of serotype and genetic background to virulence of serotype 3 and serogroup 11 pneumococcal isolates. Infect Immun. 79:4839-4849.

  Lammerts van Bueren A, Ficko-Blean E, Pluvinage B, Hehemann JH, Higgins MA, Deng L, Ogunniyi AD, Stroeher UH, El Warry N, Burke RD, Czjzek M, Paton JC, Vocadlo DJ, Boraston AB. (2011). The conformation and function of a multimodular glycogen-degrading pneumococcal virulence factor. Structure. 19:640-651.

  Iwajomo OH, Finn A, Moons P, Nkhata R, Sepako E, Ogunniyi AD, Williams NA, Heyderman RS. (2011). Deteriorating pneumococcal-specific B-cell memory in minimally symptomatic African children with HIV infection. J Infect Dis. 204:534-543.

  Harvey RM, Stroeher UH, Ogunniyi AD, Smith-Vaughan HC, Leach AJ, Paton JC. (2011). A variable region within the genome of Streptococcus pneumoniae contributes to strain-strain variation in virulence. PLoS One. 6:e19650.

  Harvey RM, Ogunniyi AD, Chen AY, Paton JC. (2011). Pneumolysin with low hemolytic activity confers an early growth advantage to Streptococcus pneumoniae in the blood. Infect Immun. 79:4122-4130.

  Ogunniyi AD, Mahdi LK, Jennings MP, McEwan AG, McDevitt CA, Van der Hoek MB, Bagley CJ, Hoffmann P, Gould KA, Paton JC. (2010). Central role of manganese in regulation of stress responses, physiology, and metabolism in Streptococcus pneumoniae. J Bacteriol. 192:4489-4497.

  Henken S, Bohling J, Ogunniyi AD, Paton JC, Salisbury VC, Welte T, Maus UA. (2010). Evaluation of biophotonic imaging to estimate bacterial burden in mice infected with highly virulent compared to less virulent Streptococcus pneumoniae serotypes. Antimicrob Agents Chemother. 54:3155-3160.

  Henken S, Bohling J, Martens-Lobenhoffer J, Paton JC, Ogunniyi AD, Briles DE, Salisbury VC, Wedekind D, Bode-Boger SM, Welsh T, Bange FC, Welte T, Maus UA. (2010). Efficacy profiles of daptomycin for treatment of invasive and noninvasive pulmonary infections with Streptococcus pneumoniae. Antimicrob Agents Chemother. 54:707-717.

  Ogunniyi AD, Grabowicz M, Mahdi LK, Cook J, Gordon DL, Sadlon TA, Paton JC. (2009). Pneumococcal histidine triad proteins are regulated by the Zn²⁺-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H. FASEB J. 23:731-738.

  Ogunniyi AD, Paton JC, Kirby AC, McCullers JA, Cook J, Hyodo M, Hayakawa Y, Karaolis DK. (2008). c-di-GMP is an effective immunomodulator and vaccine adjuvant against pneumococcal infection. Vaccine. 26:4676-4685.

  Mahdi LK, *Ogunniyi AD, LeMessurier KS, Paton JC. (2008). Pneumococcal virulence gene expression and host cytokine profiles during pathogenesis of invasive disease. Infect Immun. 76:646-657.

  Tu le N, Jeong HY, Kwon HY, Ogunniyi AD, Paton JC, Pyo SN, Rhee DK. (2007). Modulation of adherence, invasion, and tumor necrosis factor alpha secretion during the early stages of infection by Streptococcus pneumoniae ClpL. Infect Immun. 75:2996-3005.

  Steinhoff MC. (2007). Animal models for protein pneumococcal vaccine evaluation: a summary. Vaccine. 25:2465-2470.

  Ogunniyi AD, LeMessurier KS, Graham RM, Watt JM, Briles DE, Stroeher UH, Paton JC. (2007). Contributions of pneumolysin, pneumococcal surface protein A (PspA), and PspC to pathogenicity of Streptococcus pneumoniae D39 in a mouse model. Infect Immun. 75:1843-1851.

  Ogunniyi AD, Grabowicz M, Briles DE, Cook J, Paton JC. (2007). Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae. Infect Immun. 75:350-357.

  LeMessurier KS, Ogunniyi AD, Paton JC. (2006). Differential expression of key pneumococcal virulence genes in vivo. Microbiology. 152:305-311.

  Kwon HY, *Ogunniyi AD, Choi MH, Pyo SN, Rhee DK, Paton JC. (2004). The ClpP protease of Streptococcus pneumoniae modulates virulence gene expression and protects against fatal pneumococcal challenge. Infect Immun. 72:5646-5653.

  McAllister LJ, Tseng HJ, Ogunniyi AD, Jennings MP, McEwan AG, Paton JC. (2004). Molecular analysis of the psa permease complex of Streptococcus pneumoniae. Mol Microbiol. 53:889-901.

  Kwon HY, Kim SW, Choi MH, Ogunniyi AD, Paton JC, Park SH, Pyo SN, Rhee DK. (2003). Effect of heat shock and mutations in ClpL and ClpP on virulence gene expression in Streptococcus pneumoniae. Infect Immun. 71:3757-3765.

  Stroeher UH, Paton AW, Ogunniyi AD, Paton JC. (2003). Mutation of luxS of Streptococcus pneumoniae affects virulence in a mouse model. Infect Immun. 71:3206-3212.

  Chapuy-Regaud S, Ogunniyi AD, Diallo N, Huet Y, Desnottes JF, Paton JC, Escaich S, Trombe MC. (2003). RegR, a global LacI/GalR family regulator, modulates virulence and competence in Streptococcus pneumoniae. Infect Immun. 71:2615-2625.

  Duthy TG, Ormsby RJ, Giannakis E, Ogunniyi AD, Stroeher UH, Paton JC, Gordon DL. (2002). The human complement regulator factor H binds pneumococcal surface protein PspC via short consensus repeats 13 to 15. Infect Immun. 70:5604-5611.

  Ogunniyi AD, Kotlarski I, Morona R, Manning PA. (2002). Epitope analysis of the FanC subunit protein of the K99 (F5) fimbriae of enterotoxigenic Escherichia coli using a recombinant fusion technique. FEMS Immunol Med Microbiol. 34:23-31.

  Ogunniyi AD, Giammarinaro P, Paton JC. (2002). The genes encoding virulence-associated proteins and the capsule of Streptococcus pneumoniae are upregulated and differentially expressed in vivo. Microbiology 148:2045–2053.

  Brown JS, *Ogunniyi AD, Woodrow MC, Holden DW, Paton JC. (2001). Immunization with components of two iron uptake ABC transporters protects mice against systemic Streptococcus pneumoniae infection. Infect. Immun. 69:6702-6706. 

  Ogunniyi AD, Woodrow MC, Poolman JT, Paton JC. (2001). Protection against Streptococcus pneumoniae elicited by immunization with pneumolysin and CbpA. Infect. Immun. 69:5997-6003.

  Ogunniyi AD, Folland RL, Briles DE, Hollingshead SK, Paton JC. (2000). Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae. Infect. Immun. 68:3028-3033. 

• Professional Associations

  Member, Australian Society for Microbiology (MASM)

• Community Engagement

  I contributed as primary author (with one of my former PhD students, Dr Charles Plumptre as co-author) to the “cover” article of Issue 3 of e-Science magazine (http://escience.realviewdigital.com/?iid=69284#folio=1). October 2012.

  I have been actively involved in conducting tours of our laboratory to distinguished guests. During a visit to the University of 黑料社区 by His Excellency Rear Admiral Kevin Scarce, Governor of South Australia in September 2008, I showcased how we use state-of-the-art technologies to measure expression of bacterial virulence genes in infected mice, and explained how this information is enabling us to optimise the design and composition of vaccines that we are developing to prevent disease caused by Streptococcus pneumoniae.

   

Entry last updated: Tuesday, 29 Apr 2025

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